P-Selectin and CD63 Use Different Mechanisms for Delivery to Weibel-Palade Bodies
نویسندگان
چکیده
منابع مشابه
Protein mobilities and P-selectin storage in Weibel-Palade bodies.
Using fluorescence recovery after photobleaching (FRAP) we measured the mobilities of EGFP-tagged soluble secretory proteins in the endoplasmic reticulum (ER) and in individual Weibel-Palade bodies (WPBs) at early (immature) and late (mature) stages in their biogenesis. Membrane proteins (P-selectin, CD63, Rab27a) were also studied in individual WPBs. In the ER, soluble secretory proteins were ...
متن کاملVon Willebrand disease and Weibel-Palade bodies.
Von Willebrand factor (VWF) is a pivotal haemostatic protein mediating platelet adhesion to injured endothelium and carrying coagulation factor VIII (FVIII) in the circulation to protect it from premature clearance. Apart from the roles in haemostasis, VWF drives the formation of the endothelial cell specific Weibel-Palade bodies (WPBs), which serve as a regulated storage of VWF and other throm...
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Russell Jones et al recently reported immunohistochemical findings which favour the hypothesis that Kaposi's sarcoma cells are derived from lymphatic endothelium.' They stated that "ultrastructural observations of AIDS (acquired immune deficiency syndrome) and non-AIDS related Kaposi's sarcoma have failed to identify Weibel-Palade bodies commonly regarded as a marker for vascular endothelium." ...
متن کاملCD63 is a component of Weibel-Palade bodies of human endothelial cells.
Weibel-Palade bodies are secretory granules of vascular endothelial cells specialized in the storage of von Willebrand factor (vWF) and P-selectin, two adhesion proteins that can be rapidly mobilized to the cell surface by exocytosis in response to thrombin or other agonists. In this study, we attempted to identify additional components of Weibel-Palade bodies by raising monoclonal antibodies t...
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Weibel-Palade bodies (WPBs) are elongated secretory organelles specific to endothelial cells that contain von Willebrand factor (VWF) and a variety of other proteins that contribute to inflammation, angiogenesis, and tissue repair. The remarkable architecture of WPBs is because of the unique properties of their major constituent VWF. VWF is stored inside WPBs as tubules, but on its release, for...
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ژورنال
عنوان ژورنال: Traffic
سال: 2006
ISSN: 1398-9219
DOI: 10.1111/j.1600-0854.2006.00415.x